Graduate Studies in Cell and Developmental Biology

Name: Christina Takanishi Major Professor: Matthew J. Wood Department: Environmental Toxicology Lab Phone: 530-752-4380 Email: cltakanishi@ucdavis.edu Web Site: http://www.envtox.ucdavis.edu/WoodLab/woodlabhome.html
Degrees BS - University of Washington - Biology: Cell and Molecular - 2002
Research Interests
The overall goal of my research is to understand the molecular mechanisms by which environmental toxicants contribute to oxidative stress and how oxidative stress regulates the function of biological molecules and signal transduction pathways. The objective of this project is to design genetically encoded probes for the identification of proteins directly involved in the oxidative stress response.

Publications GFP-based FRET analysis in live cells. Takanishi CL, Bykova EA, Cheng W, Zheng J. Brain Res. 2006 May 26;1091(1):132-9. Epub 2006 Mar 10. Review. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels; Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. J Biol Chem. 2004 Nov 23. * signifies co-first authors. Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. EM Dewey, SL McNabb, J Ewer, GR Kuo, CL Takanishi, JW Truman, and H-W Honegger. Current Biology, 14: 1209-1213, 2004. * signifies co-first authors.