Jonathan M. Scholey Professor of Cell Biology and Biochemistry. Molecular and Cellular Biology (College of Biological Sciences) 3253 Life Sciences Addition Office 752-2271 Lab 752-2273 jmscholey@ucdavis.edu http://www.mcb.ucdavis.edu/faculty-labs/scholey/

Degrees:
1981 - PhD - MRC Laboratory of Molecular Biology, Cambridge University - Molecular Biology
1977 - BS - MRC Cell Biophysics Unit, Kings College, London University - Cell and Molecular Biology (1st class honours)

Awards:
1975 Chemistry S-level (special paper), Northampton Grammar School.
1976-1977 Sambrooke Exhibition, Department of Biophysics, Kings College, London.
1982-1985 MRC Traveling Postdoctoral Fellowship and BHF British-American Exchange Postdoctoral Fellowship
1986-1988 Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defects Foundation
1993 Lakian Summer Research Fellowship, Marine Biological Laboratory, Woods Hole, Mass.
1994, 1996 Vice-Chair and Chair, Gordon Research Conference on Motile and Contractile Systems
1995 Honorary Member of the Golden Key National Honor Society

Department and Center Affiliations:
Professor, Department of Molecular and Cellular Biology, UC Davis.
Professor, Center for Genetics and Development, UC Davis.

Professional Societies:
American Society for Cell Biology
Biophysical Society
American Society for Biochemistry and Molecular Biology
Faculty of 1000; cell biology faculty member.
Editorial Board Member, Journal of Biological Chemistry (2000-2007)
Editorial Board Member, Cell Motility and the Cytoskeleton
Editorial Board Member, Molecular Biology of the Cell

Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Biophysics
Cell and Developmental Biology

Publications:
Scholey, JM. 2003. Intraflagellar Transport. Ann. Rev. Cell Dev. Biol., 19; 423-443.

Snow, J.J., Ou, G., Gunnarson, A., Walker, M.R.S., Zhou, H.M., Brust-Mascher, I. and J.M. Scholey. 2004. Two Anterograde Intraflagellar Transport Motors Cooperate to Build Sensory Cilia on C. elegans Neurons. Nature Cell Biology. 6, 1109 - 1113.

Ou, G., Blaque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey. 2005. Functional Coordination of Intraflagellar Transport Motors. Nature, 436, 583-587.

Pan, X, Ou, G, Civelekoglu-Scholey, G, Blacque, O, Endres, N, Tao, L, Mogilner, A, Leroux, M, Vale, RD and Scholey, JM. 2006. Mechanism of Transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. Journal of Cell Biology, 174: 1035-1045.

Brust-Mascher, I., Civelekoglu-Scholey, G., Kwon, M., Mogilner, A and J.M. Scholey. 2004. Model for Anaphase B: Role of three Mitotic Motors in a Switch from Poleward Flux to Spindle Elongation. Proc. Natl. Acad. Sci (USA). 101, 15938-15943.

Civelekoglu-Scholey, G., D.J. Sharp, A. Mogilner and J.M. Scholey. 2006. Model for Chromosome Motility in Drosophila Embryos: Adaptation of a General Mechanism for Rapid Mitosis. Biophys. J. 90: 3966 - 3982.

Tao, L, A. Mogilner, G. Civelekoglu-Scholey, R. Wollman, J. Evans, H. Stahlberg, J.M. Scholey. 2006. A Homotetrameric Kinesin-5, KLP61F, Bundles Microtubules and Antagonizes Ncd in Motility Assays. Current Biology.16: 2293-2302

Cheerambathur, D.K., Civelekoglu-Scholey, G., Brust-Mascher, I., Sommi, P., Mogilner, A. and J.M., Scholey. 2007. Quantitative Analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient. Journal of Cell Biology, 177: 995 - 1004.

Van den Wildenberg, S., Tao, L., Kapitein, L.C., Schmidt, C.F., Scholey, J.M. and E.J.G. Peterman. 2008. The Homotetrameric Kinesin-5, KLP61F Preferentially Crosslinks Microtubules into Antiparallel Orientations. Current Biology, 18: 1860-1864.

Cheerambathur, DK, Brust-Mascher, I, Civelekoglu-Scholey, G, and JM Scholey. 2008. Dynamic partitioning of mitotic kinesin-5 cross-linkers between microtubule-bound and freely diffusing states. Journal of Cell Biology, 182: 429-436.

Research Interests:
Cell biology, molecular biology, biophysics and biochemistry. Mitosis, Ciliogenesis, Intracellular Transport and Motor Protein Function. Specific Projects: 1. Mechanisms of Mitosis in the Drosophila embryo: 2. Kinesin-2 Motors, Intraflagellar Transport and Sensory Cilium Assembly in C. elegans neurons. We study these problems using a combination of technical approaches including protein biochemistry, microscopy, molecular biology, genetics and quantitative modeling.
http://www.mcb.ucdavis.edu/faculty-labs/scholey/

Courses Taught:
MCB 143 Cell Biophysics (Current)
MCB 221D Cell Biochemistry (current)
BIS 102 Biochemistry: Structure and Function of Biomolecules (1993-2000)
BIS 104 Cell Biology (1998-2000)
MCB 142 Advanced Cell Biology: Motile and Contractile Systems (1990-1993)
BIS 1A Introductory Molecular Biology (1989-1992)