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Wolf-Dietrich Heyer
Professor of Microbiology Microbiology (College of Biological Sciences) 3251 Life Sciences Addition Office Tel. 752-3001 Lab wdheyer@ucdavis.edu http://micro.ucdavis.edu/heyer/ |
![[Picture of Wolf-Dietrich Heyer]](/FacultyProfiles/Common/PersonalImages/1502.jpg)
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Degrees:
1995 - Habilitation - University of Bern (Switzerland) - Microbiology & Molecular Genetics
1985 - PhD - University of Bern. Switzerland - Biology
1982 - Diploma - Free University of Berlin (Germany) - Biology
Awards:
1989 Richard A. Smith Award for Outstanding Scientific Achievement (Dana-Farber Cancer Institute, Harvard Medical School, USA)
1995 Eduard-Adolf-Stein Award for the best Habilitation at the Philosophical-Natural Sciences Faculty of the University of Bern (CH) 1990-1995
1997 Theodor-Kocher Price for the best "Young Researcher at the University of Bern 1997"
2000 Chancellor's Fellow 2000-2005, University of California, Davis
2002 Outstanding Teaching Award, Biochemistry and Molecular Biology Graduate Students
Department and Center Affiliations:
Section of Microbiology
Center for Genetics and Development
Section of Molecular and Cellular Biology
UC Davis Cancer Center
Professional Societies:
American Association for the Advancement of Science (AAAS)
Genetics Society of America
American Society of Microbiology
American Society for Biochemistry and Molecular Biology
Deutscher Hochschulverband
Gesellschaft fuer Biochemie und Molekularbiologie
Grad Group Affiliations and Specialties:
Biochemistry and Molecular Biology
Cell and Developmental Biology
Genetics
Microbiology
Research Interests:
Double-stranded DNA breaks (DSBs) are among the most genotoxic lesions and can be generated by ionizing radiation, drugs, or cellular processes. In eukaryotes, several pathways compete for the repair of such lesions. Homologous recombination is the critical DSB repair pathway in yeasts and an important DSB repair pathway in all eukaryotes studied. We are using primarily Saccharomyces cerevisiae as a model system and employ genetical, molecular, and biochemical methods to elucidate the molecular mechanism of homologous recombination and recombinational DNA repair and its regulation by the DNA damage checkpoints.
http://micro.ucdavis.edu/heyer/
Laboratory Personnel:
Our laboratory is located in LS 3243, LS 3249, LS 3144, LS 3116. My office is LS 3165. - The members of my group are: R. Alexeeva, Terrence Bennett, S. Ceballos, K. Ehmsen, Dr. Clare Fasching, Bryan Gibson, K. Herzberg, X. Li, Dr. J. Liu, J. Mar, Dr. E. Nadezhdin, Derya Ozes, Janki Patel, Dr. L. Peng, Erin Schwartz, Shiv Shukla, Dr. Jessica Sneeden, W. Wright, Dr. X. Zhang
http://micro.ucdavis.edu/heyer/
Teaching Interests:
Yeast physiology and genetics. Molecular genetics. DNA metabolism.
Courses Taught:
BIS 101 Genes and Gene Expression
MCB 221C Molecular Genetics
GGG 201C Molecular Genetics
MIC 275 Seminar in DNA Repair and Recombination
GGG 295 Seminar in Molecular Genetics
MIC 298 Advanced concepts in DNA metabolism
Publications:
Herzberg, K., Bashkirov, V.I., Rolfsmeier, M., Haghnazari, E., McDonald, W.H., Anderson, S., Bashkirova, E.V.,, Yates, J.R. 3rd, and Heyer, W.-D. (2006) Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks. Mol. Cell. Biol. 26, 8396-8409.
Galkin, V.E., Wu, J., Zhang, X.-P., Qian, X., He, Y., Yu, X., Heyer, W.-D., Luo,, Y., and Egelman, E.H. (2006) The RAD51/RadA N-terminal Domain Activates Nucleoprotein Filaments. Structure 14, 983-992. [Cover iIlustration and featured Preview by Wyman, C. (2006) Monomer Networking Activates Recombinases. Structure 14, 949-950]
Li, X.., Zhang, X.-P., Solinger, J.A., Kiianitsa, K., Yu, X., Egelman, E.H., and Heyer, W.-D. (2007) Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics. Nucleic Acids Res. 35, 4124-4140.