Faculty Profile

Peter Cala
Professor and Chair
Physiology and Membrane Biology
4136 Tupper Hall
Office 752-1285
Lab
pmcala@ucdavis.edu
http://www.physiology.ucdavis.edu/cala/index.html
[Picture of Peter Cala]
Sodium-Proton exchange (NHE1), Structure-Function, cell volume and pH regulation, Ion transport

Degrees:
1974 - PhD - Case Western Reserve University - Physiology
1970 - BA - Case Western Reserve University - Biology/Chemistry

Awards:
1994-2004 NIH MERIT award
1999 Research Mentor Award: UCDMC
2000 Leader of the Membrane Biology Initiative, UCDSOM
2003-2005 Association of Chairs of Physiology Departments: President

Professional Societies:
Americam Physiological Society
Association of Chairs of Physiology Departments (ACDP: past president)

Grad Group Affiliations and Specialties:
Cell and Developmental Biology
Molecular, Cellular, and Integrative Physiology

Publications:
2003 Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576.

2004 Pedersen, S.F., Cala, P.M. Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1; lessons from erythrocytes. J. Exp. Zoolog. Part A Comp. Exp. Biol. 2004 Jul 1; 301(7):569-78.

2005 Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 288: C57-C64.

2006 Pedersen, S.F., M.E. O’Donnell, S.E. Anderson and P.M. Cala. Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain and blood. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R1-R25.

2006 Holt, M.E., S.A. King, P.M. Cala and S.E. Pedersen. Regulation of the Pleuronectes americanus Na+/H+ exchanger by osmotic shrinkage, beta-adrenergic stimuli, and inhibition of the Ser/Thre protein phosphatases. Cell. Biochem. Biophys. 45: 1-18.

2007 King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27): 19716-27. Epub 2007 May 10.

2008 Ortiz-Acevedo A, Rigor III RR, Maldonado HM, Cala PM. Activation of Na +/H+ and K+/H+ Exchange by Calyculin A in Amphiuma tridactylum Red Blood Cells; implications for the control of volume-induced ion flux activity. Am J Physiol Cell Physiol, 284: C-1123-32.

Research Interests:
Ion transport, Na/H exchange (NHE1). NHE1 structure-function relationships. Cell volume and pH regulation. Hypoxic and ischemic cell damage. Cytoprotection. Signal transduction. Membrane biochemistry. Nuclear magnetic resonance (NMR) spectroscopy. Tumor biology.

Teaching Interests:


Membrane transport theory. Electroneutral and conductive transport.

Courses Taught:
Med HP400 Medical Physiology - Term(s): Winter
PGG 210A General/Membrane Physiology - Term(s): Fall